PLS Scientist I (Mass Spectrometry)

Summary

We seek a highly motivated analytical chemist with significant experience in mass spectrometry of biological molecules to partner with our clients in their effort to discover and develop novel medicines such as organic molecules, peptides and proteins, oligonucleotides and mRNA, or more complicated medicines combining multiple classes of molecules (e.g. nanoparticles). Our clients include biotechnology and pharmaceutical companies from new startups to those with global operations working in the areas of cancer, vaccines, and rare genetic diseases. This individual will develop analytical methods for the characterization and testing of candidate therapeutics. Competitive applicants will be able to demonstrate an in-depth knowledge of mass spectrometry theory and technology, creative problem solving, an ability to collaborate in a cross-functional team, and clearly communicate scientific results. This is a full-time bench scientist position in Woburn, MA at the Scientist 1 level.

Responsibilities:

• Independently design and execute experiments, analyze data, and understand the reliability of results.
• Present results and planned experiments clearly and concisely both verbally and in written documents.
• Maintain a strong awareness of scientific literature relevant to expertise and assigned client projects.
• Continuously improve research and development skills and advance technical capabilities of Pace.
• Strive to meet agreed-upon timelines and regularly communicate progress to other stakeholders.

An Ideal Candidate will possess skills in the following areas:

• Hands on experience operating and maintaining a variety of mass spectrometers (e.g. Sciex QQQ/Q-Trap, Waters Q-TOF, Thermo Orbitrap)
• Proficient use of acquisition and analysis software (Analyst, Unifi, Xcalibur, Empower, Chromeleon, Biopharma Finder, Progenesis, etc.).
• Development of LC-MS and LC-MS/MS methods for the quantitation of biological molecules in complex biologic matrices (e.g. serum, plasma, urine, CSF, tissue, etc.).
• Development of LC-MS methods to determine the identity, purity, and measure the concentration of the drug substance and impurities in formulated drugs.
• Characterize of therapeutic proteins (Glycosylation and other post-translational modifications, peptide mapping, disulfide bonds, sequence) and nucleic acids (sequence, mRNA 5'-capping structure)
• Understand the scientific principles and technical capabilities of mass spectrometry with application to diverse biological molecules including peptides, proteins, and nucleic acids (e.g., siRNA, gRNA, mRNA).

Required Education and/or Experience:

• Ph.D. in analytical chemistry, biochemistry, chemical biology, or closely related discipline. M.S. candidates with 3+ years of industry experience and Ph.D. candidates with 0 - 2 years' experience will be considered.
• Established track record of significant contributions as an individual technical expert as well as the ability to thrive in a multi-disciplinary team environment.
• Outstanding written and oral communication skills as well as polished presentation skills.
• Flexibility and outstanding time management skills.
• Background maintaining and troubleshooting scientific instruments and equipment.

PHYSICAL/MENTAL REQUIREMENTS:

The physical demands described herein are representative of those that must be met by an employee to successfully perform the essential functions of the job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Mobility to work in a lab and office setting, use standard office and lab equipment and stamina to sit for extended periods of time; exerting up to 20 pounds of force occasionally and/or up to 10 pounds of force frequently to lift, carry, push, pull or move objects; vision to read printed materials and computer screens; and hearing and speech to communicate in person or over the telephone.

WORKING ENVIRONMENT:

Work is performed in a lab and office setting. Work is subject to chemicals, fumes, gasses, noxious odors and related items in a lab setting.

OFCCP Statement - Pace Analytical is an Equal Opportunity Employer and will not discriminate against any applicant for employment on the basis of race, age, religion, sex, veterans, individuals with disabilities, sexual orientation, or gender identity.