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Staff Research Associate II - Neurodegenerative Diseases

University of California - San Francisco Campus and Health
United States, California, San Francisco
March 17, 2024

Staff Research Associate II - Neurodegenerative Diseases

Institute for Neurodegenerative Diseases

Full Time


Job Summary

We are seeking a laboratory technician/research associate, who will work with the Southworth lab and collaborate with other laboratories in the IND. The person in this position will support the research efforts focused on the characterization of neurodegenerative disease-associated tau fibrils. This individual will be engaged in direct research efforts, through recombinant protein expression and purification, electron microscopy, fluorescence screening assays and tau amyloid fibrillization assays. The successful candidate should have knowledge or experience in the skills related to this research emphasis including protein expression in e. coli, protein purification, and protein fibrilization or aggregation using thioflavin T fluorescence. In addition, he/she must be highly motivated and have excellent communication and organizational skills. Prior experience with protein purification methods, negative stain electron microscopy and protein fibrilization assays is required.

To see the salary range for this position (we recommend that you make a note of the job code and use that to look up):

Please note: The compensation ranges listed online for roles not covered by a bargaining unit agreement are very wide, however a job offer will typically fall in the range of 80% - 120% of the established mid-point. An offer will take into consideration the experience of the final candidate AND the current salary level of individuals working at UCSF in a similar role.

For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range.

To learn more about the benefits of working at UCSF, including total compensation, please visit:

Department Description

The Institute for Neurodegenerative Diseases (IND) at UCSF is pursuing a cutting-edge blend of basic science and clinical medicine to provide outstanding care to those suffering from neurodegenerative diseases. Founded in 1999, the IND is committed to creating therapeutics that will halt diseases such as Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease and dementia resulting from traumatic brain injuries. The IND is poised to make serious contributions to this struggle at the frontier of neuroscience and medicine. The mission of the Institute for Neurodegenerative Diseases is to discover causes and develop cures for these illnesses with an innovative program of basic research and clinical medicine. The IND is directed by Nobel Laureate Stanley B. Prusiner, MD.

Required Qualifications

  • BA/BS in Biochemistry, Molecular Biology or a related science and knowledge of, or experience with, the basic techniques or methods required by the position; and/or an equivalent combination of education and experience.Excellent oral and written communication skills.
  • One or more years of recent, directly related work experience
  • Knowledge or experience in a research laboratory, including developing and maintaining biological and chemical safety protocols.
  • Experience in protein expression using e. coli and protein purification procedures
  • Experinece negative stain electron microsopy
  • Experience in vitro protein fibrillization or aggregation assays
  • Knowledge of commonly-used concepts, practices, and procedures in protein biochemistry.
  • Computer literacy on both Macintosh and PC, MS-Office suite and basic statistical analysis.

Preferred Qualifications

  • Experience in high throughput differential scanning fluorimetry (HT-DSF).
  • Experience in implementing Laboratory Safety Guidelines and Procedures.

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world's leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

Pride Values

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence - also known as our PRIDE values.

In addition to our PRIDE values, UCSF is committed to equity - both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at

Join us to find a rewarding career contributing to improving healthcare worldwide.

Equal Employment Opportunity

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.



Job Code and Payroll Title

009617 SRA 2 NEX

Job Category

Research and Scientific

Bargaining Unit

University Professional Technical Employees - Research Support Professionals Unit (UPTE-RX)

Employee Class





Mission Bay (SF)



Shift Length

8 Hours

Additional Shift Details

M-F 8:30am - 5:00pm