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Benaroya Research Institute | Diversity Employer

BRI is powering discoveries in order to learn how to rebalance the immune system in all autoimmune and immune system diseases. Our ultimate goal is to achieve a healthy immune system for each individual.

As a world-renowned, non-profit research institute we advance science that will predict, prevent, reverse and cure diseases of the immune system. Our Centers for Discovery accelerate progress through laboratory breakthroughs in immunology that can be translated to clinical therapies. BRI is a leader in collaborative initiatives and frequently partners with global research institutes to drive research forward and power possibilities.


BRI is a 501(c)3 independent nonprofit medical research institute affiliated with the Virginia Mason Health System, located on the Virginia Mason Seattle campus. BRI is governed by a volunteer board of community members focused on seeing that the following vision, mission and strategy are achieved.

A healthy immune system for every individual.

To advance the science that will predict, prevent, reverse and cure diseases of the immune system.

BRI’s strategy to achieve its vision and mission is to engage in scientific discovery related to how the immune system works, both in health and disease. Questions being addressed include how the immune system works to protect the body from disease and ways the immune system can cause disease.

Our scientific approach involves:

  • Basic discovery using model systems to understand the fundamental nature of the immune system
  • Translation of genetic, environmental, lifestyle and immunologic factors to variables responsible for disease development
  • Interventions in the clinic that are controlled and assessed to accelerate development of therapies
  • Integration and analysis of complex data within and across studies to drive scientific breakthroughs
  • We are building on our prior success, expanding our mission to encompass immune health, autoimmune and allergic diseases and the impact of immune interventions to prevent, treat and ultimately cure disease.


At BRI we recognize that to achieve our mission of one day preventing and curing immune disease, we need to understand differences: between individuals with and without disease, as diseases progress over time and before and after treatment.

We have a large and growing biorepository of samples that allows us to investigate these differences, across populations all the way down to single cells. We generate and analyze huge datasets profiling genetics, gene expression patterns and frequency of specific types of immune cells that either protect or promote immune disease.

From this we are able to build a more complete understanding of factors influencing health, disease, treatment response and the variations we find across individuals.


  • Persistent Inquiry
  • Innovation & Agility
  • Constant Collaboration
  • Integrity & Respect

Why Work at BRI

Benaroya Research Institute (BRI) is a world leader in human immunology. We have a bold mission: To predict, prevent, reverse and cure immune system diseases. We’re currently hiring new team members who are passionate about changing the course of immune system diseases.
At BRI, we study everything from autoimmune disease to cancer to COVID-19. And we examine the immune system as a whole — in healthy people and in people with disease — aiming to understand how these disorders start and how to rebalance the immune system back to health.
Equipped with innovative tools and robust biorepositories, our team spends every day tackling some of immunology’s biggest mysteries and working toward our vision: A healthy immune system for everyone.

In support of our goal to accelerate discovery in autoimmune disease research, BRI fosters a work environment focused on collaboration, education and training. Learn more about becoming a member of our team.


    Benaroya Research Institute at Virginia Mason (BRI) values a strong culture of collaboration, both among our diverse staff and with research partners near and far. This synergistic environment extends beyond the lab or office, as the institute provides opportunities to get to know colleagues and volunteer/participate in community events.
    BRI is a core part of the dynamic life sciences community in Seattle. Many BRI researchers have clinical affiliations with Virginia Mason, affiliate appointments with the University of Washington and train University of Washington Immunology PhD students.
    BRI’s location on the Virginia Mason Hospital campus is adjacent to downtown Seattle, the thriving cultural, financial and business hub of the region. This highly walkable area is also close to mass transit routes that access the greater Puget Sound area.
    Being at BRI means living in the heart of the stunning Pacific Northwest – an ideal place for those who love exploring. It means being surrounded by the vibrancy and sophistication of one of the most livable cities in the country, near some of the most breathtaking natural beauty anyone can find. When seeking the perfect urban or outdoor pursuit, there are endless possibilities.
    • Land Acknowledgement
      • With respect and honor BRI acknowledges that we are on the traditional land of the first people of Seattle, the Duwamish People past and present and honor with gratitude the land itself and the Duwamish Tribe.
    • DEI Council Mission Statement:
      • We are committed to creating an environment where all people are, and perceive themselves to be, welcomed, valued, respected and heard in order to develop, contribute to and achieve aligned organizational and scientific goals.

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